DVL2

Chr 17p13.1

dishevelled segment polarity protein 2

MANE:: ENST00000005340.10

OMIM: 602151 ↗NCBI: 1856 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DVL2 · O14641

v62025-08-01

Predicted Aligned Error matrix for DVL2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.7/ 100

Low

736 residues

Confidence breakdown

Very high(≥ 90)17%
Confident(70–90)19%
Low(50–70)8%
Very low(< 50)57%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Skeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Limb disorders
Monogenic hearing loss

Disease associations (Open Targets)

Robinow syndrome
0.43
pelvic organ prolapse
0.11
hepatocellular carcinoma
0.10
colorectal carcinoma
0.09
breast cancer
0.08
breast carcinoma
0.08
rheumatoid arthritis
0.08
colonic neoplasm
0.07
glioblastoma
0.07
malignant colon neoplasm
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Segment polarity protein dishevelled homolog DVL-2

Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling