DYNC1I1

Chr 7q21.3

dynein cytoplasmic 1 intermediate chain 1

Aliases:: DNCIC1
MANE:: ENST00000447467.6

OMIM: 603772 ↗NCBI: 1780 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DYNC1I1 · O14576

v62025-08-01

Predicted Aligned Error matrix for DYNC1I1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

70.9/ 100

Confident

645 residues

Confidence breakdown

Very high(≥ 90)14%
Confident(70–90)52%
Low(50–70)12%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

viral infectious disease
0.46
vertebral joint disorder
0.31
vertebral disorder
0.31
COVID-19
0.30
response to vaccine
0.30
spinal stenosis
0.30
viral pneumonia
0.29
bacterial arthritis
0.29
osteoarthritis
0.28
arthropathy
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cytoplasmic dynein 1 intermediate chain 1

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores