DYNC1I2

Chr 2q31.1

dynein cytoplasmic 1 intermediate chain 2

Aliases:: DIC74
MANE:: ENST00000397119.8

OMIM: 603331 ↗NCBI: 1781 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DYNC1I2 · Q13409

v62025-08-01

Predicted Aligned Error matrix for DYNC1I2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.7/ 100

Confident

638 residues

Confidence breakdown

Very high(≥ 90)17%
Confident(70–90)52%
Low(50–70)10%
Very low(< 50)22%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodevelopmental disorder with microcephaly and structural brain anomalies
0.70
neurodegenerative disease
0.48
viral infectious disease
0.46
lysosomal storage disease
0.43
neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies
0.43
Parkinson disease
0.32
Alzheimer disease
0.32
multiple sclerosis
0.32
tuberculosis
0.26
Pain
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cytoplasmic dynein 1 intermediate chain 2

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity)