DYRK1B

Chr 19q13.2

dual specificity tyrosine phosphorylation regulated kinase 1B

Aliases:: MIRK
MANE:: ENST00000323039.10

OMIM: 604556 ↗NCBI: 9149 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

DYRK1B · Q9Y463

v62025-08-01

Predicted Aligned Error matrix for DYRK1B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.0/ 100

Confident

629 residues

Confidence breakdown

Very high(≥ 90)51%
Confident(70–90)9%
Low(50–70)5%
Very low(< 50)35%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Familial diabetes
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Monogenic diabetes
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Severe early-onset obesity
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

metabolic syndrome
0.70
neurodegenerative disease
0.54
lysosomal storage disease
0.45
Alzheimer disease
0.33
Parkinson disease
0.33
multiple sclerosis
0.33
hereditary disease
0.19
myoepithelial tumor
0.11
cancer
0.10
ovarian carcinoma
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661). During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815). Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1)