AlphaFold predicted structure
DZIP1L · Q8IYY4
Mean pLDDT
68.8/ 100
Low
767 residues
Confidence breakdown
- Very high(≥ 90)32%
- Confident(70–90)25%
- Low(50–70)7%
- Very low(< 50)36%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
DZIP1L
Chr 3q22.3DAZ interacting zinc finger protein 1 like
- Aliases:
- FLJ32844, DZIP2
- MANE:
- ENST00000327532.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Cystic kidney disease
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
polycystic kidney disease 5
0.64kidney disorder
0.60autosomal recessive polycystic kidney disease
0.47preeclampsia
0.29hereditary disease
0.19nephronophthisis
0.08familial idiopathic steroid-resistant nephrotic syndrome
0.07Meckel syndrome
0.07renal cysts and diabetes syndrome
0.07Senior-Boichis syndrome
0.07
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Cilium assembly protein DZIP1L
Involved in primary cilium formation (PubMed:19852954, PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (PubMed:28530676)
Diseases associated with DZIP1L
Curated MONDO disease pages that list DZIP1L among their top associated genes.