EEF2

Chr 19p13.3

eukaryotic translation elongation factor 2

Aliases:: EEF-2
MANE:: ENST00000309311.7

OMIM: 130610 ↗NCBI: 1938 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

EEF2 · P13639

v62025-08-01

Predicted Aligned Error matrix for EEF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.8/ 100

Confident

858 residues

Confidence breakdown

Very high(≥ 90)65%
Confident(70–90)32%
Low(50–70)4%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Hydrocephalus
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Ataxia and cerebellar anomalies - narrow panel
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Hereditary ataxia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Hereditary ataxia with onset in adulthood
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

spinocerebellar ataxia type 26
0.60
primary cutaneous T-cell non-Hodgkin lymphoma
0.54
neoplasm
0.54
hairy cell leukemia
0.53
neurodegenerative disease
0.49
Hydrocephalus
0.46
Parkinson disease
0.43
Alzheimer disease
0.42
acute myeloid leukemia
0.41
multiple sclerosis
0.41

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Elongation factor 2

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721)