eukaryotic translation initiation factor 3 subunit B
Annotations refreshed 1 month ago.
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPaediatric disorders - additional genes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedinjury
familial isolated congenital asplenia
complex neurodevelopmental disorder
Tetralogy of Fallot
cleft lip
neoplasm
gastric cancer
prostate carcinoma
Familial prostate cancer
prostate cancer
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Eukaryotic translation initiation factor 3 subunit B
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)
EIF3B · P55884
Mean pLDDT
73.3/ 100
Confident
814 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
