EIF3M

Chr 11p13

eukaryotic translation initiation factor 3 subunit M

Aliases:: hfl-B5, FLJ29030, GA17, TANGO7
MANE:: ENST00000531120.6

OMIM: 609641 ↗NCBI: 10480 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

EIF3M · Q7L2H7

v62025-08-01

Predicted Aligned Error matrix for EIF3M — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

55.3/ 100

Low

374 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)6%
Low(50–70)71%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

hypothyroidism
0.37
major depressive disorder
0.28
digestive system disorder
0.27
coronary atherosclerosis
0.27
Hernia
0.26
atrial fibrillation
0.26
Hernia of the abdominal wall
0.24
metabolic syndrome
0.23
smoking initiation
0.22
diaphragmatic hernia
0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Eukaryotic translation initiation factor 3 subunit M

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)