EPAS1

Chr 2p21

endothelial PAS domain protein 1

Aliases:: MOP2, PASD2, HIF2A, HLF, bHLHe73
MANE:: ENST00000263734.5

OMIM: 603349 ↗NCBI: 2034 ↗Ensembl ↗

Predicted protein structure

AlphaFold predicted structure

EPAS1 · Q99814

v62025-08-01

Predicted Aligned Error matrix for EPAS1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.6/ 100

Low

870 residues

Confidence breakdown

Very high(≥ 90)29%
Confident(70–90)6%
Low(50–70)12%
Very low(< 50)53%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Detailed annotations are loading.

We have HGNC metadata for this gene, but the deeper annotations (ClinVar, gnomAD, PanelApp, …) populate when someone uses the GenoLens extension to look up this gene. Install the extension or check back in a moment.