ERBIN

Chr 5q12.3

erbb2 interacting protein

Aliases:: LAP2
MANE:: ENST00000284037.10

OMIM: 606944 ↗NCBI: 55914 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

ERBIN · Q96RT1

v62025-08-01

Predicted Aligned Error matrix for ERBIN — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

55.7/ 100

Low

1,412 residues

Confidence breakdown

Very high(≥ 90)31%
Confident(70–90)6%
Low(50–70)4%
Very low(< 50)60%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

cancer
0.60
alcohol drinking
0.34
ovarian neoplasm
0.32
adolescent idiopathic scoliosis
0.27
food allergy
0.26
musculoskeletal system disorder
0.25
urolithiasis
0.25
tuberculosis
0.24
diabetes mellitus
0.24
placenta praevia
0.24

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Erbin

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes (PubMed:23524970)