ERG

Chr 21q22.2

ETS transcription factor ERG

Aliases:: erg-3, p55
MANE:: ENST00000288319.12

OMIM: 165080 ↗NCBI: 2078 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

ERG · P11308

v62025-08-01

Predicted Aligned Error matrix for ERG — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

59.3/ 100

Low

479 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)15%
Low(50–70)13%
Very low(< 50)54%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary lymphoedema
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

lymphatic malformation 14
0.60
B-cell acute lymphoblastic leukemia
0.48
multiple sclerosis
0.47
osteoarthritis, hip
0.45
neurodegenerative disease
0.43
total hip arthroplasty
0.42
prostate carcinoma
0.40
abdominal aortic aneurysm
0.40
prostate intraepithelial neoplasia
0.39
Dupuytren Contracture
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transcriptional regulator ERG

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure