ESR2

Chr 14q23.2-q23.3

estrogen receptor 2

Aliases:: NR3A2, Erb, ER-beta
MANE:: ENST00000341099.6

OMIM: 601663 ↗NCBI: 2100 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ESR2 · Q92731

v62025-08-01

Predicted Aligned Error matrix for ESR2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.3/ 100

Low

530 residues

Confidence breakdown

Very high(≥ 90)46%
Confident(70–90)10%
Low(50–70)4%
Very low(< 50)40%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Differences in sex development
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Familial Meniere Disease
Monogenic hearing loss

Disease associations (Open Targets)

breast cancer
0.62
osteoporosis
0.61
postmenopausal osteoporosis
0.58
menopause
0.57
Dyspareunia
0.56
Atrophy
0.55
neoplasm
0.49
breast carcinoma
0.49
primary ovarian failure
0.48
hypogonadism
0.47

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Estrogen receptor beta

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560)