AlphaFold predicted structure
ETV2 · O00321
Mean pLDDT
55.6/ 100
Low
342 residues
Confidence breakdown
- Very high(≥ 90)20%
- Confident(70–90)6%
- Low(50–70)10%
- Very low(< 50)65%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
ETV2
Chr 19q13.12ETS variant transcription factor 2
- Aliases:
- ER71
- MANE:
- ENST00000402764.6
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Abnormal vertebral morphology
0.32polydactyly
0.32Abnormal heart morphology
0.32hypoplastic left heart syndrome
0.32myocardial infarction
0.09neoplasm
0.08glioblastoma
0.08prostate carcinoma
0.04central nervous system cancer
0.04glioma
0.04
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
ETS translocation variant 2
Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'