F11

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Bleeding and platelet disorders

  BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

• Factor XI deficiency

  BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

• Inherited bleeding disorders

  BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

Disease associations (Open Targets)

• factor XI deficiency

  0.84

• congenital factor XI deficiency

  0.77

• venous thromboembolism

  0.64

• deep vein thrombosis

  0.57

• pulmonary embolism

  0.54

• heart disorder

  0.53

• phlebitis

  0.53

• Thrombophlebitis

  0.53

• hereditary angioedema

  0.52

• cardiovascular disorder

  0.51

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with F11

Curated MONDO disease pages that list F11 among their top associated genes.

• heart disorderRare
• ischemic strokeRare
• venous thromboembolismRare