F13A1

Chr 6p25.1

coagulation factor XIII A chain

MANE:: ENST00000264870.8

OMIM: 134570 ↗NCBI: 2162 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

F13A1 · P00488

v62025-08-01

Predicted Aligned Error matrix for F13A1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.9/ 100

Very high

732 residues

Confidence breakdown

Very high(≥ 90)70%
Confident(70–90)27%
Low(50–70)2%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Factor XIII deficiency
BIALLELIC, autosomal or pseudoautosomal
Inherited bleeding disorders
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Familial hypercholesterolaemia

Disease associations (Open Targets)

Factor XIII subunit A deficiency
0.81
factor XIII, A subunit, deficiency of
0.74
congenital factor XIII deficiency
0.53
thrombophilia due to thrombin defect
0.49
hemorrhage
0.46
neurodegenerative disease
0.39
Rare genetic coagulation disorder
0.37
DNA methylation
0.34
placental retention
0.33
hyperpituitarism
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Coagulation factor XIII A chain

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin