AlphaFold predicted structure
F13B · P05160
Mean pLDDT
80.6/ 100
Confident
661 residues
Confidence breakdown
- Very high(≥ 90)15%
- Confident(70–90)72%
- Low(50–70)7%
- Very low(< 50)6%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
F13B
Chr 1q31.3coagulation factor XIII B chain
- Aliases:
- FXIIIB
- MANE:
- ENST00000367412.2
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Bleeding and platelet disorders
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomalFactor XIII deficiency
BIALLELIC, autosomal or pseudoautosomalInherited bleeding disorders
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Disease associations (Open Targets)
congenital factor XIII deficiency
0.69age-related macular degeneration
0.43macular degeneration
0.35coagulation protein disease
0.34factor XIII deficiency
0.33cholesteatoma
0.33hereditary disease
0.19psoriasis
0.12thrombotic disease
0.12retinal disorder
0.08
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Coagulation factor XIII B chain
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin