F2R

Chr 5q13.3

coagulation factor II thrombin receptor

Aliases:: TR, CF2R, PAR1, PAR-1
MANE:: ENST00000319211.5

OMIM: 187930 ↗NCBI: 2149 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

F2R · P25116

v62025-08-01

Predicted Aligned Error matrix for F2R — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.6/ 100

Confident

425 residues

Confidence breakdown

Very high(≥ 90)46%
Confident(70–90)21%
Low(50–70)7%
Very low(< 50)25%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Bleeding and platelet disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

myocardial infarction
0.55
neurodegenerative disease
0.49
peripheral arterial disease
0.47
stroke disorder
0.38
Recurrent thrombophlebitis
0.37
preeclampsia
0.27
von Willebrand disease 1
0.19
dermatitis
0.16
neoplasm
0.12
coronary artery disorder
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Proteinase-activated receptor 1

High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (PubMed:10079109). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (PubMed:30568593, PubMed:34831181)