F3

Chr 1p21.3

coagulation factor III, tissue factor

Aliases:: CD142, TF
MANE:: ENST00000334047.12

OMIM: 134390 ↗NCBI: 2152 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

F3 · P13726

v62025-08-01

Predicted Aligned Error matrix for F3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.8/ 100

Confident

295 residues

Confidence breakdown

Very high(≥ 90)68%
Confident(70–90)11%
Low(50–70)7%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Thrombophilia with a likely monogenic cause
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

Disease associations (Open Targets)

cervical cancer
0.56
cancer
0.38
neoplasm
0.38
placental abruption
0.30
spontaneous coronary artery dissection
0.26
macular degeneration
0.20
ovarian cancer
0.10
retinitis pigmentosa
0.08
rheumatoid arthritis
0.08
colorectal cancer
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tissue factor

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade