AlphaFold predicted structure
F5 · P12259
Mean pLDDT
61.9/ 100
Low
2,224 residues
Confidence breakdown
- Very high(≥ 90)22%
- Confident(70–90)31%
- Low(50–70)5%
- Very low(< 50)42%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
F5
Chr 1q24.2coagulation factor V
- Aliases:
- fV
- MANE:
- ENST00000367797.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Bleeding and platelet disorders
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomalFactor V deficiency
BIALLELIC, autosomal or pseudoautosomalInherited bleeding disorders
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomalThrombophilia with a likely monogenic cause
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomalIntellectual disability
Disease associations (Open Targets)
thrombophilia due to activated protein C resistance
0.80congenital factor V deficiency
0.78factor V deficiency
0.77ischemic stroke
0.66Venous thrombosis
0.59venous thromboembolism
0.56pulmonary embolism
0.55deep vein thrombosis
0.55Sepsis
0.55Thromboembolism
0.53
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Coagulation factor V
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin
Diseases associated with F5
Curated MONDO disease pages that list F5 among their top associated genes.