F7

Chr 13q34

coagulation factor VII

MANE:: ENST00000346342.8

OMIM: 613878 ↗NCBI: 2155 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

F7 · P08709

v62025-08-01

Predicted Aligned Error matrix for F7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.1/ 100

Confident

466 residues

Confidence breakdown

Very high(≥ 90)49%
Confident(70–90)29%
Low(50–70)14%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Factor VII deficiency
BIALLELIC, autosomal or pseudoautosomal
Inherited bleeding disorders
BIALLELIC, autosomal or pseudoautosomal
Familial hypercholesterolaemia

Disease associations (Open Targets)

factor VII deficiency
0.85
congenital factor VII deficiency
0.78
hemophilia B
0.55
hemophilia A
0.55
blood coagulation disease
0.50
Abnormality of coagulation
0.44
Abnormal bleeding
0.39
Glanzmann thrombasthenia
0.38
coagulation protein disease
0.37
intracerebral hemorrhage
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Coagulation factor VII

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951)