AlphaFold predicted structure
F8 · P00451
Mean pLDDT
60.8/ 100
Low
2,351 residues
Confidence breakdown
- Very high(≥ 90)31%
- Confident(70–90)20%
- Low(50–70)4%
- Very low(< 50)46%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
F8
Chr Xq28coagulation factor VIII
- Aliases:
- FVIII, DXS1253E, HEMA
- MANE:
- ENST00000360256.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Bleeding and platelet disorders
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesFactor VIII deficiency
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesInherited bleeding disorders
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Disease associations (Open Targets)
hemophilia A
0.91hemophilia
0.74hemophilia B
0.69thrombophilia, X-linked, due to factor 8 defect
0.66hemorrhage
0.58immune system disorder
0.57Sepsis
0.55severe hemophilia A
0.55mild hemophilia A
0.52Abnormality of coagulation
0.49
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Coagulation factor VIII
Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa
Diseases associated with F8
Curated MONDO disease pages that list F8 among their top associated genes.