F9

Chr Xq27.1

coagulation factor IX

Aliases:: FIX
MANE:: ENST00000218099.7

OMIM: 300746 ↗NCBI: 2158 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

F9 · P00740

v62025-08-01

Predicted Aligned Error matrix for F9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.3/ 100

Confident

461 residues

Confidence breakdown

Very high(≥ 90)51%
Confident(70–90)25%
Low(50–70)13%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Factor IX deficiency
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Inherited bleeding disorders
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

hemophilia B
0.89
hemophilia A
0.76
thrombophilia, X-linked, due to factor 9 defect
0.75
x-linked warfarin sensitivity
0.69
hemorrhage
0.58
venous thromboembolism
0.52
hemophilia b leyden
0.50
hemophilia
0.47
Venous thrombosis
0.47
cartilage disease
0.46

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Coagulation factor IX

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa (PubMed:8295821, PubMed:2592373, PubMed:20121197, PubMed:20121198, PubMed:1730085, PubMed:19846852, PubMed:39880037)