FAAH2

Chr Xp11.21

fatty acid amide hydrolase 2

Aliases:: RP11-479E16.1, FLJ31204, FAAH-2
MANE:: ENST00000374900.5

OMIM: 300654 ↗NCBI: 158584 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FAAH2 · Q6GMR7

v62025-08-01

Predicted Aligned Error matrix for FAAH2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

93.9/ 100

Very high

532 residues

Confidence breakdown

Very high(≥ 90)85%
Confident(70–90)11%
Low(50–70)3%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

hypogonadism
0.30
hypertensive disorder
0.24
type 2 diabetes mellitus
0.22
systemic lupus erythematosus
0.06
Atrophy/Degeneration affecting the central nervous system
0.04
depressive disorder
0.03
heart disorder
0.02
neoplasm
0.02
nonpapillary renal cell carcinoma
0.01
psychiatric disorder
0.01

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fatty-acid amide hydrolase 2

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates