FASLG

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• COVID-19 research

  BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

• Cytopenia - NOT Fanconi anaemia

  BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

• Primary immunodeficiency or monogenic inflammatory bowel disease

  BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

Disease associations (Open Targets)

• autoimmune lymphoproliferative syndrome type 1

  0.70

• autoimmune lymphoproliferative syndrome

  0.60

• systemic lupus erythematosus

  0.44

• open-angle glaucoma

  0.42

• immunodeficiency 98 with autoinflammation, X-linked

  0.35

• lung cancer

  0.33

• atopic eczema

  0.29

• celiac disease

  0.29

• allergic rhinitis

  0.28

• psoriasis

  0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)