FCGR2A

Chr 1q23.3

Fc gamma receptor IIa

Aliases:: CD32, CD32A, IGFR2, CDw32, Fc-gamma-RIIa
MANE:: ENST00000271450.12

OMIM: 146790 ↗NCBI: 2212 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FCGR2A · P12318

v62025-08-01

Predicted Aligned Error matrix for FCGR2A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.9/ 100

Confident

317 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)10%
Low(50–70)14%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Primary immunodeficiency or monogenic inflammatory bowel disease

Disease associations (Open Targets)

systemic lupus erythematosus
0.53
ulcerative colitis
0.53
inflammatory bowel disease
0.53
rheumatoid arthritis
0.43
Kawasaki disease
0.43
ulcerative proctosigmoiditis
0.41
Crohn disease
0.38
cutaneous leishmaniasis
0.37
ankylosing spondylitis
0.37
colitis
0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Low affinity immunoglobulin gamma Fc region receptor II-a

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens

Curated MONDO disease pages that list FCGR2A among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with FCGR2A