FCMR

Chr 1q32.1

Fc mu receptor

Aliases:: TOSO, FcmuR
MANE:: ENST00000367091.8

OMIM: 606015 ↗NCBI: 9214 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FCMR · O60667

v62025-08-01

Predicted Aligned Error matrix for FCMR — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

64.9/ 100

Low

390 residues

Confidence breakdown

Very high(≥ 90)31%
Confident(70–90)8%
Low(50–70)19%
Very low(< 50)42%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

hypothyroidism
0.30
neoplasm
0.08
primary pigmented nodular adrenocortical disease
0.07
pigmented nodular adrenocortical disease, primary, 3
0.07
congenital adrenal hyperplasia
0.06
B-cell chronic lymphocytic leukemia
0.06
clear cell renal carcinoma
0.05
diffuse large B-cell lymphoma
0.05
cancer
0.05
congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Immunoglobulin mu Fc receptor

High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (PubMed:19858324, PubMed:22675200, PubMed:36949194, PubMed:37095205). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:21908732, PubMed:28230186). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (PubMed:19858324, PubMed:22675200, PubMed:25601920, PubMed:30840890)