AlphaFold predicted structure
FCN3 · O75636
Mean pLDDT
86.5/ 100
Confident
299 residues
Confidence breakdown
- Very high(≥ 90)70%
- Confident(70–90)10%
- Low(50–70)8%
- Very low(< 50)12%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
FCN3
Chr 1p36.11ficolin 3
- Aliases:
- FCNH, HAKA1
- MANE:
- ENST00000270879.9
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
immunodeficiency due to ficolin3 deficiency
0.53complement deficiency
0.37rheumatic heart disease
0.23hepatocellular carcinoma
0.13microcephaly
0.11neoplasm
0.10systemic lupus erythematosus
0.10leprosy
0.08cancer
0.08gout
0.08
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Ficolin-3
Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11907111, PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically binds N-Acetylglucosamine (GlcNAc,) GalNAc (N-acetylgalactosamine) and D-fucose on the surface of pathogens, as well as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (PubMed:17215869)