AlphaFold predicted structure
FDPS · P14324
Mean pLDDT
85.4/ 100
Confident
419 residues
Confidence breakdown
- Very high(≥ 90)78%
- Confident(70–90)4%
- Low(50–70)1%
- Very low(< 50)17%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
FDPS
Chr 1q22farnesyl diphosphate synthase
- MANE:
- ENST00000368356.9
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Familial disseminated superficial actinic porokeratosis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownRare genetic inflammatory skin disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
porokeratosis 9, multiple types
0.64disseminated superficial actinic porokeratosis
0.62osteoporosis
0.61postmenopausal osteoporosis
0.60plasma cell myeloma
0.60bone Paget disease
0.60prostate carcinoma
0.59metastasis
0.59bone fracture
0.58prostate cancer
0.57
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Farnesyl pyrophosphate synthase
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate
Diseases associated with FDPS
Curated MONDO disease pages that list FDPS among their top associated genes.