FEZ1

Chr 11q24.2

fasciculation and elongation protein zeta 1

Aliases:: UNC-76
MANE:: ENST00000278919.8

OMIM: 604825 ↗NCBI: 9638 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FEZ1 · Q99689

v62025-08-01

Predicted Aligned Error matrix for FEZ1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

67.4/ 100

Low

392 residues

Confidence breakdown

Very high(≥ 90)19%
Confident(70–90)30%
Low(50–70)25%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

actinic keratosis
0.26
Intellectual disability
0.26
infection
0.08
HIV-1 infection
0.08
type 2 diabetes mellitus
0.08
asthma
0.06
Alzheimer disease
0.06
schizophrenia
0.06
Parkinson disease
0.05
vascular disorder
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fasciculation and elongation protein zeta-1

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules