FEZF1

Chr 7q31.32

FEZ family zinc finger 1

MANE:: ENST00000442488.7

OMIM: 613301 ↗NCBI: 389549 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FEZF1 · A0PJY2

v62025-08-01

Predicted Aligned Error matrix for FEZF1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

56.0/ 100

Low

475 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)38%
Low(50–70)11%
Very low(< 50)51%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Kallmann syndrome
0.69
hypogonadotropic hypogonadism
0.37
type 2 diabetes mellitus
0.31
diabetes mellitus
0.31
smoking initiation
0.28
attention deficit-hyperactivity disorder
0.22
substance abuse
0.22
hereditary disease
0.19
risk-taking behaviour
0.14
non-small cell lung carcinoma
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fez family zinc finger protein 1

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity)