FEZF2

Chr 3p14.2

FEZ family zinc finger 2

Aliases:: FLJ10142, FKSG36, TOF, FEZL, Zfp312
MANE:: ENST00000283268.8

OMIM: 607414 ↗NCBI: 55079 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FEZF2 · Q8TBJ5

v62025-08-01

Predicted Aligned Error matrix for FEZF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

54.0/ 100

Low

459 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)37%
Low(50–70)9%
Very low(< 50)55%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

neurodegenerative disease
0.49
neurodevelopmental disorder
0.31
placental abruption
0.31
bone fracture
0.28
Abnormality of the integument
0.14
Abnormality of the skeletal system
0.13
biliary tract disorder
0.12
mathematical ability
0.12
liver disorder
0.12
hypomyelinating leukodystrophy 5
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fez family zinc finger protein 2

Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity)