FGA

Chr 4q31.3

fibrinogen alpha chain

MANE:: ENST00000403106.8

OMIM: 134820 ↗NCBI: 2243 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FGA · P02671

v62025-08-01

Predicted Aligned Error matrix for FGA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

60.3/ 100

Low

866 residues

Confidence breakdown

Very high(≥ 90)22%
Confident(70–90)21%
Low(50–70)12%
Very low(< 50)46%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Hereditary systemic amyloidosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Inherited bleeding disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Periodic fever syndromes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Thrombophilia with a likely monogenic cause
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

familial dysfibrinogenemia
0.79
Familial renal amyloidosis
0.76
familial visceral amyloidosis
0.76
congenital afibrinogenemia
0.75
familial hypodysfibrinogenemia
0.66
congenital fibrinogen deficiency
0.62
Familial afibrinogenemia
0.60
cancer
0.59
Hypofibrinogenemia
0.59
Noonan syndrome
0.53

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fibrinogen alpha chain

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways