FGF16

Chr Xq21.1

fibroblast growth factor 16

MANE:: ENST00000439435.3

OMIM: 300827 ↗NCBI: 8823 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FGF16 · O43320

v62025-08-01

Predicted Aligned Error matrix for FGF16 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.6/ 100

Confident

207 residues

Confidence breakdown

Very high(≥ 90)60%
Confident(70–90)12%
Low(50–70)14%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Limb disorders
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Skeletal dysplasia
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Fetal anomalies
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

syndactyly type 8
0.68
cancer
0.60
bone development disease
0.59
ovarian carcinoma
0.37
female reproductive endometrioid cancer
0.37
acrocephalosyndactyly
0.37
craniosynostosis
0.37
rheumatoid arthritis
0.24
fibroblastic disorder
0.17
neoplasm
0.13

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fibroblast growth factor 16

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development