FGF17

Chr 8p21.3

fibroblast growth factor 17

Aliases:: FGF-13
MANE:: ENST00000359441.4

OMIM: 603725 ↗NCBI: 8822 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

FGF17 · O60258

v62025-08-01

Predicted Aligned Error matrix for FGF17 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.2/ 100

Confident

216 residues

Confidence breakdown

Very high(≥ 90)63%
Confident(70–90)13%
Low(50–70)21%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Hypogonadotropic hypogonadism (GMS)
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
Unknown
Hypogonadotropic hypogonadism
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Kallmann syndrome
0.69
cancer
0.60
bone development disease
0.60
hypogonadotropic hypogonadism
0.42
ovarian carcinoma
0.37
acrocephalosyndactyly
0.37
female reproductive endometrioid cancer
0.37
craniosynostosis
0.37
spermatogenic failure
0.19
male infertility
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fibroblast growth factor 17

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development