FGF4

Chr 11q13.3

fibroblast growth factor 4

Aliases:: K-FGF, HBGF-4, HST, HST-1, KFGF
MANE:: ENST00000168712.3

OMIM: 164980 ↗NCBI: 2249 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

FGF4 · P08620

v62025-08-01

Predicted Aligned Error matrix for FGF4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.5/ 100

Confident

206 residues

Confidence breakdown

Very high(≥ 90)60%
Confident(70–90)11%
Low(50–70)14%
Very low(< 50)15%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cancer
0.60
bone development disease
0.60
neurodegenerative disease
0.53
thoracic dysostosis, isolated
0.42
craniosynostosis
0.37
ovarian carcinoma
0.37
female reproductive endometrioid cancer
0.37
acrocephalosyndactyly
0.37
Jeune syndrome
0.37
Abnormality of the liver
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fibroblast growth factor 4

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (By similarity)