AlphaFold predicted structure
FGF5 · P12034
Mean pLDDT
75.7/ 100
Confident
268 residues
Confidence breakdown
- Very high(≥ 90)49%
- Confident(70–90)9%
- Low(50–70)25%
- Very low(< 50)18%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
FGF5
Chr 4q21.21fibroblast growth factor 5
- MANE:
- ENST00000312465.12
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Paediatric disorders - additional genes
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
cancer
0.60trichomegaly
0.60bone development disease
0.60hypertensive disorder
0.58atrial fibrillation
0.56coronary artery disorder
0.55essential hypertension
0.54preeclampsia
0.53androgenetic alopecia
0.52stroke disorder
0.51
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Fibroblast growth factor 5
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity)
Diseases associated with FGF5
Curated MONDO disease pages that list FGF5 among their top associated genes.