FGF9

Chr 13q12.11

fibroblast growth factor 9

MANE:: ENST00000382353.6

OMIM: 600921 ↗NCBI: 2254 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

FGF9 · P31371

v62025-08-01

Predicted Aligned Error matrix for FGF9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.8/ 100

Confident

208 residues

Confidence breakdown

Very high(≥ 90)64%
Confident(70–90)9%
Low(50–70)9%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Rare syndromic craniosynostosis or isolated multisuture synostosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Skeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

multiple synostoses syndrome
0.74
cancer
0.61
bone development disease
0.60
female reproductive endometrioid cancer
0.50
ovarian carcinoma
0.47
craniosynostosis
0.39
acrocephalosyndactyly
0.37
hypertensive disorder
0.33
open-angle glaucoma
0.31
essential hypertension
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fibroblast growth factor 9

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors