FHOD3

Chr 18q12.2

formin homology 2 domain containing 3

Aliases:: FHOS2, KIAA1695, FLJ22297, FLJ22717
MANE:: ENST00000590592.6

OMIM: 609691 ↗NCBI: 80206 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FHOD3 · Q2V2M9

v62025-08-01

Predicted Aligned Error matrix for FHOD3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

63.6/ 100

Low

1,422 residues

Confidence breakdown

Very high(≥ 90)26%
Confident(70–90)24%
Low(50–70)8%
Very low(< 50)42%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hypertrophic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Paediatric or syndromic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Dilated and arrhythmogenic cardiomyopathy

Disease associations (Open Targets)

cardiomyopathy, familial hypertrophic, 28
0.76
hypertrophic cardiomyopathy
0.63
Abnormality of the cardiovascular system
0.38
hereditary disease
0.34
atrial fibrillation
0.33
Phenotypic abnormality
0.30
Loss of consciousness
0.29
deficiency anemia
0.29
Abnormal abdomen morphology
0.27
adolescent idiopathic scoliosis
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Formin-like protein 3

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignment