AlphaFold predicted structure
FIBP · O43427
Mean pLDDT
91.9/ 100
Very high
364 residues
Confidence breakdown
- Very high(≥ 90)84%
- Confident(70–90)9%
- Low(50–70)6%
- Very low(< 50)1%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
FIBP
Chr 11q13.1FGF1 intracellular binding protein
- Aliases:
- FGFIBP
- MANE:
- ENST00000357519.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
tall stature-intellectual disability-renal anomalies syndrome
0.68Large hands
0.26Macrocephaly
0.26Overgrowth
0.26coloboma
0.26learning disability
0.26Abnormal facial shape
0.26hereditary disease
0.19metabolic syndrome
0.16psoriasis
0.12
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Acidic fibroblast growth factor intracellular-binding protein
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity)