FILIP1

Chr 6q14.1

filamin A interacting protein 1

Aliases:: FILIP, KIAA1275
MANE:: ENST00000237172.12

OMIM: 607307 ↗NCBI: 27145 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FILIP1 · Q7Z7B0

v62025-08-01

Predicted Aligned Error matrix for FILIP1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

66.6/ 100

Low

1,213 residues

Confidence breakdown

Very high(≥ 90)31%
Confident(70–90)21%
Low(50–70)9%
Very low(< 50)39%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neuromuscular disorder, congenital, with dysmorphic facies
0.70
osteoarthritis, hip
0.39
osteoarthritis
0.37
Intellectual disability
0.37
arthrogryposis multiplex congenita
0.37
osteoarthritis, knee
0.31
total hip arthroplasty
0.31
major depressive disorder
0.28
atrial fibrillation
0.26
medical procedure
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Filamin-A-interacting protein 1

By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A