FLG2

Chr 1q21.3

filaggrin 2

Aliases:: IFPS
MANE:: ENST00000388718.5

OMIM: 616284 ↗NCBI: 388698 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FLG2 · Q5D862

v62025-08-01

Predicted Aligned Error matrix for FLG2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

32.9/ 100

Very low

2,391 residues

Confidence breakdown

Very high(≥ 90)3%
Confident(70–90)1%
Low(50–70)0%
Very low(< 50)96%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Epidermolysis bullosa and congenital skin fragility
BIALLELIC, autosomal or pseudoautosomal
Ichthyosis and erythrokeratoderma
BIALLELIC, autosomal or pseudoautosomal
Palmoplantar keratodermas
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

peeling skin syndrome 6
0.70
peeling skin syndrome
0.37
generalized peeling skin syndrome
0.37
peeling skin syndrome type A
0.37
atopic eczema
0.29
allergic disease
0.26
sign or symptom
0.24
asthma
0.23
Abnormality of the skeletal system
0.22
skin disorder
0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Filaggrin-2

Essential for normal cell-cell adhesion in the cornified cell layers (PubMed:29758285). Important for proper integrity and mechanical strength of the stratum corneum of the epidermis (PubMed:29505760)