FLI1

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Bleeding and platelet disorders

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Inherited bleeding disorders

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Cytopenia - NOT Fanconi anaemia

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

• Rare hemorrhagic disorder due to a constitutional platelet anomaly

  0.76

• Ewing sarcoma

  0.42

• Thrombocytopenia

  0.41

• osteosarcoma

  0.39

• Ewing sarcoma/peripheral primitive neuroectodermal tumor

  0.38

• rhabdomyosarcoma

  0.37

• desmoplastic small round cell tumor

  0.37

• alveolar rhabdomyosarcoma

  0.37

• synovial sarcoma

  0.37

• leiomyosarcoma

  0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with FLI1

Curated MONDO disease pages that list FLI1 among their top associated genes.

• osteosarcomaRare