FLII

Chr 17p11.2

FLII actin remodeling protein

Aliases:: FLI, FLIL, Fli1, MGC39265
MANE:: ENST00000327031.9

OMIM: 600362 ↗NCBI: 2314 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FLII · Q13045

v62025-08-01

Predicted Aligned Error matrix for FLII — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.9/ 100

Confident

1,269 residues

Confidence breakdown

Very high(≥ 90)40%
Confident(70–90)41%
Low(50–70)6%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Paediatric or syndromic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal
Dilated and arrhythmogenic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cardiomyopathy, dilated, 2j
0.60
Abnormality of the skeletal system
0.36
dilated cardiomyopathy
0.31
neurodegenerative disease
0.29
Marfan syndrome
0.12
Ewing sarcoma
0.11
myopia
0.11
Flexion contracture
0.11
pathological myopia
0.11
neoplasm
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein flightless-1 homolog

Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1 (PubMed:14966289). Involved in estrogen hormone signaling