fms related receptor tyrosine kinase 3
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Moderate Evidence (Amber)
Cytopenias and congenital anaemias
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownacute myeloid leukemia
hepatocellular carcinoma
gastrointestinal stromal tumor
neoplasm
renal cell carcinoma
cancer
myelofibrosis
acute lymphoblastic leukemia
primary myelofibrosis
hypothyroidism
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Receptor-type tyrosine-protein kinase FLT3
Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways
Curated MONDO disease pages that list FLT3 among their top associated genes.
FLT3 · P36888
Mean pLDDT
75.9/ 100
Confident
993 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
