FLT3LG

Chr 19q13.33

fms related receptor tyrosine kinase 3 ligand

MANE:: ENST00000597551.6

OMIM: 600007 ↗NCBI: 2323 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

FLT3LG · P49771

v62025-08-01

Predicted Aligned Error matrix for FLT3LG — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.3/ 100

Confident

235 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)14%
Low(50–70)17%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cancer
0.52
immunodeficiency 125
0.38
neurodegenerative disease
0.37
alcohol drinking
0.13
neoplasm
0.12
rheumatoid arthritis
0.09
Parkinson disease
0.08
acute respiratory distress syndrome
0.08
multiple system atrophy
0.08
systemic lupus erythematosus
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fms-related tyrosine kinase 3 ligand

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs)