FMO3

Chr 1q24.3

flavin containing dimethylaniline monoxygenase 3

Aliases:: FMOII
MANE:: ENST00000367755.9

OMIM: 136132 ↗NCBI: 2328 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

FMO3 · P31513

v62025-08-01

Predicted Aligned Error matrix for FMO3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

95.6/ 100

Very high

532 residues

Confidence breakdown

Very high(≥ 90)92%
Confident(70–90)6%
Low(50–70)2%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Undiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomal
Rare genetic inflammatory skin disorders
BIALLELIC, autosomal or pseudoautosomal
Childhood onset dystonia, chorea or related movement disorder

Disease associations (Open Targets)

trimethylaminuria
0.79
inborn errors of metabolism
0.37
hereditary disease
0.34
atrial fibrillation
0.08
diabetes mellitus
0.08
systemic sclerosis
0.07
hyperaldosteronism
0.06
Isolated anophthalmia - microphthalmia
0.06
hereditary neutrophilia
0.05
X-linked recessive ocular albinism
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Flavin-containing monooxygenase 3

Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269)