FN1

Chr 2q35

fibronectin 1

Aliases:: MSF, CIG, LETS, GFND2, FINC
MANE:: ENST00000354785.11

OMIM: 135600 ↗NCBI: 2335 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

FN1 · P02751

v62025-08-01

Predicted Aligned Error matrix for FN1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.6/ 100

Low

2,477 residues

Confidence breakdown

Very high(≥ 90)5%
Confident(70–90)56%
Low(50–70)23%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Proteinuric renal disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Skeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

spondylometaphyseal dysplasia, 'corner fracture' type
0.80
glomerulopathy with fibronectin deposits 2
0.74
cancer
0.63
coronary artery disorder
0.58
Noonan syndrome
0.53
hypertrophic cardiomyopathy
0.52
Costello syndrome
0.50
fibronectin glomerulopathy
0.48
coronary atherosclerosis
0.48
bacterial infectious disease
0.47

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fibronectin

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617)

Curated MONDO disease pages that list FN1 among their top associated genes.

eye disorderRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with FN1