FOSL2

Chr 2p23.2

FOS like 2, AP-1 transcription factor subunit

Aliases:: FRA2, FLJ23306
MANE:: ENST00000264716.9

OMIM: 601575 ↗NCBI: 2355 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FOSL2 · P15408

v62025-08-01

Predicted Aligned Error matrix for FOSL2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

61.7/ 100

Low

326 residues

Confidence breakdown

Very high(≥ 90)19%
Confident(70–90)6%
Low(50–70)38%
Very low(< 50)36%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bilateral congenital or childhood onset cataracts
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Ectodermal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

aplasia cutis-enamel dysplasia syndrome
0.72
hypertensive disorder
0.48
hair color
0.48
allergic rhinitis
0.48
Crohn disease
0.46
inflammatory bowel disease
0.43
rosacea
0.43
neurodegenerative disease
0.41
Eczematoid dermatitis
0.41
atopic eczema
0.41

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Fos-related antigen 2

Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity)