FOXF2

Chr 6p25.3

forkhead box F2

Aliases:: FREAC2
MANE:: ENST00000645481.2

OMIM: 603250 ↗NCBI: 2295 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

FOXF2 · Q12947

v62025-08-01

Predicted Aligned Error matrix for FOXF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

56.4/ 100

Low

444 residues

Confidence breakdown

Very high(≥ 90)16%
Confident(70–90)7%
Low(50–70)19%
Very low(< 50)59%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Familial cerebral small vessel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

stroke disorder
0.45
ischemic stroke
0.43
cerebral artery occlusion
0.37
cerebral arterial disease
0.37
response to anti-thyroid drug
0.31
Drug-induced agranulocytosis
0.31
Transient global amnesia
0.30
cerebrovascular disorder
0.29
small vessel stroke
0.29
vertebral column disorder
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Forkhead box protein F2

Probable transcription activator for a number of lung-specific genes (PubMed:8626802). Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (PubMed:29374064)