FOXG1

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Childhood onset dystonia, chorea or related movement disorder

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• DDG2P

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Early onset dystonia

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Early onset or syndromic epilepsy

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Fetal anomalies

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Intellectual disability

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Severe microcephaly

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Adult onset dystonia, chorea or related movement disorder

+2 more panels — install the extension to see the full list inline on any page.

Disease associations (Open Targets)

• FOXG1 disorder

  0.81

• Rett syndrome

  0.75

• hereditary disease

  0.54

• neurodevelopmental disorder

  0.43

• mathematical ability

  0.43

• undetermined early-onset epileptic encephalopathy

  0.38

• atypical Rett syndrome

  0.38

• placenta praevia

  0.38

• Strabismus

  0.34

• Abnormality of the nervous system

  0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with FOXG1

Curated MONDO disease pages that list FOXG1 among their top associated genes.

• placenta praeviaRare